Prenatal hypoxia impairs the early postnatal development of the carotid chemoafferent pathway

Developmental plasticity of the carotid chemoafferent pathway in rats that are hypoxic during the prenatal period.

The chemoreflex pathway undergoes postnatal maturation, and the perinatal environment plays a critical role in shaping respiratory control system. We investigated the role of prenatal hypoxia on the maturation of the chemoreflex neural circuits regulating ventilation in rat. Effects of hypoxia (10% O2) from the 5th to the 20th day of gestation were studied on male offspring at birth and on post...

Effect of chronic hypoxia during the early stage of incubation on prenatal and postnatal parameters related to ascites syndrome in broiler chickens

To investigate the influence of hypoxia during the early stage of incubation on embryonic developmentand hatching events, and consequently on incidence of ascites in broiler chickens, one thousand fertile eggswere incubated in two commercial incubators. Half the eggs were incubated in a low altitude incubator untilhatched. The second half were incubated in a high altitude incubator until day 10...

Postnatal development of neural chemoafferent pathway and respiration is altered following prenatal nicotine exposure in rats

Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia.

Exposing newborn rats to postnatal hyperoxia (60% O2) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our understanding of the carotid chemoreceptor afferent neural input in this depressed response with different durations of postnatal hyperoxic exposure. Rats were exposed from a few days before birth to...

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development

Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in neurons and their supportive cells in developing the vertebrate Central Nervous System (CNS).  Objectives: This study investigates the HDAC11 pote...